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Table 5 Genome scan results (lod score ≥ 1.75) for lipids with and without medication correction by ethnicity: the HyperGEN study

From: An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

     Excluding medicated Including medicated
Phenotype Chromosome cM (from p-ter) Marker No. of sibs Lod score No. of sibs Lod score
        Medication unadjusted Medication adjusted
African Americans         
   TC 6 53.81 GGAA15B08 1803 2.03 1889 2.18 2.66
  21 36.77 ATA27F01   2.58   2.02 2.15
  22 4.06 AFM217XF4   1.95   1.82 2.04
   HDL-C 9 75.88 GATA89A11 1797 1.44 1884 2.11 2.07
   LDL-C 2 132.58 GATA27A12 1786 1.46 1871 1.62 1.79
  6 73.13 GATA11E02   2.22   2.36 1.81
  21 57.77 GATA70B08   1.73   1.93 1.77
  22 4.06 AFM217XF4   1.50   1.80 1.83
   TG 6 73.13 GATA11E02 1803 1.89 1888 2.18 2.06
  9 44.28 GATA87E02   2.00   1.05 0.93
  11 131.26 AFM157XH6   3.08   2.73 2.71
Whites         
   TC 5 172.13 GATA7H10 1682 0.98 1924 0.73 1.92
  14 91.62 GATA30A03   0.58   2.07 0.44
   HDL-C 1 274.53 GATA50F11 1678 1.92 1919 1.00 0.84
  8 0.73 AFM143XD8   1.24   2.19 1.67
  20 32.94 GATA81E09   1.72   1.02 1.76
   LDL-C 9 88.92 GATA81C04 1682 1.80 1858 0.43 0.59
  1. BMI = Body Mass Index; TC = Total Cholesterol; HDL-C = High Density Lipoprotein Cholesterol; LDL-C = Low Density Lipoprotein Cholesterol; TG = Triglycerides