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Table 2 Average effects estimated from published clinical trails by ethnicity for HMG-CoA reductase inhibitors and fibric acid derivatives

From: An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

Medication Phenotype African Americans Non-African Americans * All
   No. of pts pooled Average effect (mg/dl) ± SE No. of pts pooled Average effect (mg/dl) ± SE No. of pts pooled Average effect (mg/dl) ± SE
HMG-CoA reductase inhibitors TC 572 -51.4 ± 11.2 10637 -52.1 ± 13.2 16811 -50.7 ± 13.9
  LDL-C 572 -47.9 ± 7.2 10637 -49.9 ± 13.6 16811 -48.1 ± 13.9
  HDL-C 572 +0.4 ± 1.7 10637 +2.3 ± 0.5 16811 +2.0 ± 0.8
  TG 572 -18.8 ± 4.2 10637 -18.4 ± 3.7 16811 -19.7 ± 4.5
Fibric acid derivatives (Gemfibrozil) TC - - 477 -46.1 ± 8.6 2573 -20.1 ± 15.3
  LDL-C - - 477 -40.1 ± 7.0 2573 -11.4 ± 14.4
  HDL-C - - 477 +5.9 ± 1.8 2573 +3.1 ± 1.6
  TG - - 477 -57.1 ± 14.1 2573 -59.0 ± 10.4
  1. * Non-African Americans mainly include Whites, Hispanic.
  2. TC =Total Cholesterol; HDL-C = High Density Lipoprotein Cholesterol; LDL-C = Low Density Lipoprotein Cholesterol; TG = Triglycerides.