|
Medication
|
Phenotype
|
African Americans
|
Non-African Americans *
|
All
|
|---|
| | |
No. of pts pooled
|
Average effect (mg/dl) ± SE
|
No. of pts pooled
|
Average effect (mg/dl) ± SE
|
No. of pts pooled
|
Average effect (mg/dl) ± SE
|
|---|
|
HMG-CoA reductase inhibitors
|
TC
|
572
|
-51.4 ± 11.2
|
10637
|
-52.1 ± 13.2
|
16811
|
-50.7 ± 13.9
|
| |
LDL-C
|
572
|
-47.9 ± 7.2
|
10637
|
-49.9 ± 13.6
|
16811
|
-48.1 ± 13.9
|
| |
HDL-C
|
572
|
+0.4 ± 1.7
|
10637
|
+2.3 ± 0.5
|
16811
|
+2.0 ± 0.8
|
| |
TG
|
572
|
-18.8 ± 4.2
|
10637
|
-18.4 ± 3.7
|
16811
|
-19.7 ± 4.5
|
|
Fibric acid derivatives (Gemfibrozil)
|
TC
|
-
|
-
|
477
|
-46.1 ± 8.6
|
2573
|
-20.1 ± 15.3
|
| |
LDL-C
|
-
|
-
|
477
|
-40.1 ± 7.0
|
2573
|
-11.4 ± 14.4
|
| |
HDL-C
|
-
|
-
|
477
|
+5.9 ± 1.8
|
2573
|
+3.1 ± 1.6
|
| |
TG
|
-
|
-
|
477
|
-57.1 ± 14.1
|
2573
|
-59.0 ± 10.4
|
- * Non-African Americans mainly include Whites, Hispanic.
- TC =Total Cholesterol; HDL-C = High Density Lipoprotein Cholesterol; LDL-C = Low Density Lipoprotein Cholesterol; TG = Triglycerides.
