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Table 2 Genotype association between rs7162140 and quantitative measures of substance dependence.

From: Variation in the gene coding for the M5 Muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults

 

n

Mean

SD

Model

p-Value (two-tailed)

Tobacco Dose

     

CC

192

74.9

55.1

Dominant

0.01

CT

73

97.0

70.9

Recessive

0.84

TT

8

76.6

35.8

  

CT|TT

81

95.0

68.4

  

Alcohol Dose

     

CC

354

20.1

21.8

Dominant

0.81

CT

161

21.1

21.1

Recessive

0.41

TT

21

16.4

16.2

  

CT|TT

182

20.6

20.7

  
  1. Alcohol dose described as units (10 g) per week. Tobacco dose described as cigarettes smoked per week. Analysis based on both dominant (TT|CT > CC) and recessive (TT > CT|CC) inheritance models using the Student's t-test (two-tailed) to measure equality of means.