Skip to main content

Table 1 Genotype associations between rs7162140 and categorical measures of substance dependence.

From: Variation in the gene coding for the M5 Muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults

 

Genotype Count

    
 

Case

Control

Model

Odds Ratio

p-Value

Nicotine Dependence

     

CC

48

144

Dominant

1.6 (0.90–2.8)

0.11

CT

24

49

Recessive

2.6 (0.65–11.0)

0.17

TT

4

4

   

Alcohol Dependence

     

CC

310

50

Dominant

1.3 (0.77–2.0)

0.36

CT

135

28

Recessive

0.95 (0.27–3.3)

0.94

TT

18

3

   

Cannabis Dependence

     

CC

40

19

Dominant

2.9 (1.1–7.4)

0.03

CT

9

13

Recessive

1.5 (0.20–11.4)

0.68

TT

2

2

   
  1. Odds ratio shown with 95% confidence intervals. Analysis based on both dominant (TT|CT > CC) and recessive (TT > CT|CC) inheritance models.