Figure 2
From: Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
Comparison of iris disease in 13 months old D2 mice and D2.Tyrp1B6GpnmbB6mice. A and D show broad-beam illumination, B and E show transillumination defects and C and F show the relative dimensions of the anterior chamber. A-C. In D2 mice, the iris disease involves iris stromal atrophy, transillumination defects and progressive depigmentation with abnormal dispersal of iris pigment into the anterior chamber. D-F. In contrast, D2.Tyrp1B6GpnmbB6mice show no iris pigment disease, transillumination defects or alteration of the anterior chamber.