Table 1 Characteristics of whole genome scans for linkage for Parkinson's disease
Reference | DeStefanoetal. [11] | Scottetal[9] | Hicksetal[13] | Pankratzetal[10] | Martinezetal[12] |
|---|---|---|---|---|---|
Source Population | US | US | Iceland | US | US + Europe |
Diagnostic criteria | UKPDS (adapted) | 2 cardinal PD-signs + exclusion criteria | 2 cardinal PD-signs + Hoen-Yahr crit. | UPDRS (II+III) Diagnosis Check List | 3 cardinal PD-signs or 2 signs and at least 30% improvement with levodpoa treatment no parkin mutations |
Family Structure | ASP | multiplex families | multiplex families | multiplex families | multiplex families |
No. of Families | 113 | 174 | 51 | 325 (170ASP) | 199 (227 ASP) |
No. of Affected | 226 | 378 | 117 | 192 | 471 |
No. of Marker | 392 | 344 | 781 | 400 SNPs | 391 |
Average distance | 11 cM | 10 cM | 8.6 cM | 10 cM | |
Analysis | MLS/NPL | MLOD | Zlr | MLS | MLS |
Significant region/markers | 9 – D9S1825 | 5q–D5S816 8p–D8S520 17q – D17S921 | 1p32–D1S231 D1S2652 | 2 – D2S206 | 2p–D2S160 5q–D5S471 6q–D6S257 7p–D7S531 11q–D11S4175 2 – D2S206 19 q – D19S902 |