Figure 3

Location of the variants identified in the 5' flanking region of Dahl S, R, and Wistar rats ENaC γ gene on the Brown Norway rat genomic sequence [15]. Position of the variants identified in the current study is highlighted in bold. Boxes represent the putative transcription factor-binding sequences; the putative binding sequences found during the present sequence analysis are labeled in bold; the factor names are written above the boxes. The first three bases for the major kidney and brain transcription start sites are italicized and bold. The translation initiation codon (+1) is underlined. TFSEARCH^® scores for the newly assigned putative binding sequences are 89.2, 87.4, and 89.0 for C/EBP a & b and CRE, respectively; 85.8 for Oct-1; 89.3 for C/EBP, 87.9 and 85.5 for CRE and C/EBPb respectively; 87.7 for Sp1, 91.0 and 87.4 for c-Myc and C/EBPb respectively; and 85.9 for USF.