TY - JOUR AU - Kahlmann, Daniel AU - Davalos-Misslitz, Ana Clara Marques AU - Ohl, Lars AU - Stanke, Frauke AU - Witte, Torsten AU - Förster, Reinhold PY - 2007 DA - 2007/06/22 TI - Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis JO - BMC Genetics SP - 33 VL - 8 IS - 1 AB - The chemokine receptor CCR7 is a key organizer of the immune system. Gene targeting in mice revealed that Ccr7-deficient animals are severely impaired in the induction of central and peripheral tolerance. Due to these defects, Ccr7-deficient mice spontaneously develop multi-organ autoimmunity showing symptoms similar to those observed in humans suffering from connective tissue autoimmune diseases. However, it is unknown whether mutations of CCR7 are linked to autoimmunity in humans. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-8-33 DO - 10.1186/1471-2156-8-33 ID - Kahlmann2007 ER -