Figure 1

Cat genomic sequence of CMAH including the 5'UTR to exon 1. Sequence generated from genomic DNA from cats of each blood type. Lower case letters represent the UTR. The six bold upper case letters are the last six nucleotides of exon 1 that are translated to the methionine start and a glycine prior to the splice with exon 2. ATG sites are underlined. The lower case in italics is the intronic 1 sequence that is the splice variant sequence found in the cDNA of Type B cats, spliced immediately upstream of the exon 2 sequence. Two GATA transcription factor sites are underlined. The mutations that are consistent with blood group phenotypes, A-217G and the T-371C, are presented in bold and underlined. One intron 1 variant and three 5' UTR mutations that are not consistent with blood types are also presented.