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Table 1 Association analysis in the extended T1D family set.

From: Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11

Gene Polymorphism

Allele 1/2c

Affected offspring

Allele 1, Transmitted (%)

Allele 1, Non-transmitted (%)

P-value TDT

Allele 1, frequency d

PAPD1

      

Rs639299a

G/A

2029

777 (48.2)

834 (51.8)

0.16

0.69

rs1963187a

A/T

2383

272 (56.1)

213 (43.9)

0.0074

0.95

rs2480285a

G/A

2642

785 (46.3)

909 (53.7)

0.0026

0.21

D10S1426a

 

1401

  

0.21

 
 

*158

 

502 (52.7)

450 (47.3)

0.092

0.27

 

*162

 

502 (48.4)

535 (51.6)

0.31

0.33

 

*166

 

420 (52.3)

383 (47.7)

0.19

0.23

D10S193a

 

1932

  

0.037

 
 

*220

 

587 (46.6)

673 (53.4)

0.015

0.28

 

*224

 

781 (52.2)

716 (47.8)

0.093

0.35

 

*226

 

363 (55.1)

296 (44.9)

0.0091

0.11

 

*228

 

185 (47.8)

202 (52.2)

0.39

0.07

rs540994 b

A/C

2096

941 (51.4)

889 (48.6)

0.22

0.45

ss48399034b

A/T

2124

178 (58.4)

127 (41.6)

0.0035

0.96

rs1047991b

G/A

2382

849 (48.1)

916 (51.9)

0.11

0.73

rs11818836b

A/G

2087

958 (52.2)

876 (47.8)

0.056

0.45

ss48399025b

A/C

2284

388 (54.0)

330 (46.0)

0.030

0.90

ss48399036b

A/G

3207

137 (55.0)

112 (45.0)

0.11

0.02

ss48399044b

T/A

2061

461 (46.6)

529 (53.4)

0.031

0.83

NRP1

      

rs13324a

A/G

2134

826 (50.6)

806 (49.4)

0.62

0.30

rs1048804a

A/G

2047

661 (47.7)

725 (52.3)

0.086

0.75

rs1010826a

A/G

2125

737 (51.9)

683 (48.1)

0.15

0.24

MYO3A

      

rs1339816 a

A/G

2107

820 (47.7)

898 (52.3)

0.060

0.35

rs2096176 a

A/G

2116

893 (47.6)

984 (52.4)

0.036

0.42

HNRPF

      

rs1416226a

A/G

2090

728 (53.5)

632 (46.5)

0.0092

0.23

SVIL

      

rs2274494a

A/G

2152

894 (47.5)

987 (52.5)

0.032

0.37

rs11600a

A/G

2147

432 (47.5)

477 (52.5)

0.14

0.13

Intergenic

      

rs787025 a

A/C

2038

237 (45.6)

283 (54.4)

0.044

0.06

BMS1L

      

rs787795a

A/G

2102

537 (53.4)

469 (46.6)

0.032

0.86

  1. a – polymorphism genotyped in the initial scan, b – polymorphisms genotyped after being identified by resequencing of the PAPD1-MAP3K8 gene region, c – alleles encoded as 1and 2 for SNPs or as size of an allele for STRs, d – allele frequency among parents of T1D patients from the UK is shown; TDT – transmission disequilibrium test