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Table 1 Genotype frequency in 3 week old B6 × BALB F2 CF and non-CF mice

From: X chromosome transmission ratio distortion in Cftr +/- intercross-derived mice

  Marker Position (Mb)a No. mice No. B6:B6 No. B6:BALB No. BALB:BALB P-valueb
F2 Non-CF 3 weeks
Females D5Mit239 107.7 707 145 292 270 5.7 × 10-15
  DXMit16 95.6 687 210 188 289 3.0 × 10-35
  D3Mit189 101.1 367 101 171 95 0.39
Males D5Mit239 107.7 358 74 192 92 0.16
  DXMit16 95.6 341 154c 0 187 0.07
  D3Mit189 101.1 364 98 176 90 0.69
F2 CF 3 weeks
Females D5Mit239 107.7 58 9 30 19 0.17
  DXMit16 95.6 56 14 31 11 0.62
  D3Mit189 101.1 54 16 23 15 0.54
Males D5Mit239 107.7 75 9 45 20 0.035
  DXMit16 95.6 79 35 0 43 0.37
  D3Mit189 101.1 75 15 40 20 0.61
  1. ataken from the Ensembl database, release 40, August 2006.
  2. bP-values obtained by standard Pearson's χ2 test comparing observed values to expected 1:2:1 ratio (B6/B6:B6/BALB:BALB/BALB) of genotypes (except for 1:1 X chromosome genotypes of male mice). B6 = C57BL/6J, BALB = BALB/cJ.
  3. c DXMit16 genotype is B6 or BALB in male mice.
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