PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle

Haase, Bianca; Doherr, Marcus G; Seuberlich, Torsten; Drögemüller, Cord; Dolf, Gaudenz; Nicken, Petra; Schiebel, Katrin; Ziegler, Ute; Groschup, Martin H; Zurbriggen, Andreas; Leeb, Tosso

doi:10.1186/1471-2156-8-15

BMC Genomic Data

Table 1 Allele, genotype, and haplotype frequencies of BSE-affected cattle and controls

From: PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle

Pooled breeds from Germany and Switzerland: German Holstein, German Fleckvieh, Swiss Schwarzfleck, Swiss Simmental × Red Holstein,
		Allele frequency				Genotype frequency
23 bp indel	n	D	I	P		D/D	D/I	I/I	P	HWE_pval
Total	1244	0.65	0.36	0.0105		0.41	0.47	0.12	0.0207	0.6559
Control	574	0.61	0.39			0.37	0.47	0.16
BSE	670	0.68	0.32			0.45	0.47	0.09
		Allele frequency				Genotype frequency
12 bp indel	n	D	I	P		D/D	D/I	I/I	P	HWE_pval
Total	1244	0.56	0.44	0.1209		0.33	0.47	0.20	0.1731	0.3931
Control	574	0.54	0.46			0.31	0.46	0.23
BSE	670	0.58	0.42			0.34	0.49	0.17
23 & 12 bp indel		Haplotype frequency
	n	D-D	D-I	I-I	P
Total	1244	0.56	0.09	0.36	0.0169
Control	574	0.54	0.07	0.39
BSE	670	0.58	0.10	0.32
Pooled breeds from Switzerland: Swiss Schwarzfleck, Swiss Simmental × Red Holstein
		Allele frequency				Genotype frequency
23 bp indel	n	D	I	P		D/D	D/I	I/I	P	HWE_pval
Total	588	0.59	0.42	0.0295		0.33	0.50	0.16	0.0614	0.6306
Control	294	0.54	0.46			0.29	0.50	0.21
BSE	294	0.63	0.37			0.37	0.51	0.12
		Allele frequency				Genotype frequency
12 bp indel	n	D	I	P		D/D	D/I	I/I	P	HWE_pval
Total	588	0.48	0.52	0.4091		0.24	0.48	0.28	0.5795	0.6396
Control	294	0.46	0.54			0.23	0.46	0.31
BSE	294	0.50	0.50			0.25	0.50	0.25
23 & 12 bp indel		Haplotype frequency
	n	D-D	D-I	I-I	P
Total	588	0.48	0.11	0.42	0.0218
Control	294	0.46	0.08	0.46
BSE	294	0.49	0.14	0.37
Pooled Brown breeds from Germany and Switzerland: German Brown, Swiss Brown
		Allele frequency				Genotype frequency
23 bp indel	n	D	I	P		D/D	D/I	I/I	P	HWE_pval
Total	516	0.42	0.59	0.5357		0.20	0.43	0.37	0.3574	0.0630
Control	288	0.40	0.60			0.17	0.46	0.37
BSE	228	0.43	0.57			0.24	0.39	0.38
		Allele frequency				Genotype frequency
12 bp indel	n	D	I	P		D/D	D/I	I/I	P	HWE_pval
Total	516	0.23	0.78	0.1432		0.04	0.38	0.58	0.1317	0.4117
Control	288	0.21	0.79			0.02	0.38	0.60
BSE	228	0.26	0.74			0.07	0.39	0.54
23 & 12 bp indel		Haplotype frequency
	n	D-D	D-I	I-I	P
Total	516	0.23	0.19	0.58	0.2439
Control	288	0.21	0.20	0.59
BSE	228	0.26	0.17	0.57

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