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Figure 1 | BMC Genetics

Figure 1

From: Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E

Figure 1

Linkage disequilibrium (LD) analysis for haplotypes across the human class I region on chromosome 6. Column A depicts individual alleles detected and analyzed within the Panel 2 subjects. The horizontal scale to the right of column A presents normalized LD (D') between 2 loci (HLA-A and HLA-E, and HLA-C and HLA-B, respectively). To the right of each D' value (â–ˇ), the relevant paired loci with significant association (P < 0.005 in bold color; P < 0.05 in weaker color) are depicted (column B). To the right of column B, the horizontal D' scale depicts the association (â–ˇ) between HLA-E and paired HLA-Cw/HLA-B alleles, with the associated alleles listed in column C where strong significant associations (P < 0.005 to < 0.00002) are listed in bold color, weaker associations (P < 0.05) in intermediate color, and non-significant associations indicated by lightest color. To the right of column C, the horizontal D' scale depicts the association (â–ˇ) between HLA-A, -E, -Cw and -B representing HLA class I haplotypes over 1.4 Mb, where the associated alleles are listed in column D (P < 0.0001 in bold, P < 0.002 in intermediate, and P < 0.05 in weak colors). The red lines indicate HLA-A alleles which are not in LD with HLA-E upon 2 locus analysis, but become significantly associated in the context of the 4 locus haplotypes including HLA-Cw/HLA-B.

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