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Table 3 Predicted Amino Acid Sequence Comparison

From: Genomic and expression analysis of multiple Sry loci from a single Rattus norvegicus Y chromosome

Sry1

MEGH VKRPMN AFMVWSRGER RKLAQQNPSM QNSEISK H LG YQWKSLTEAE

Sry2

   Q         M    GE H L QQ  S  Q S    Q   YQ  S    

Sry3

   H         M    GE  R L QQ  S  Q S    Q   YQ  S     

Sry3B1

   H         M    GE  R L QQ  S  Q S    Q   YQ  S     

Sry3b

   H         M    GE  R L QQ  S  Q S    Q   YQ  S     

Sry3C

   H         M    GE  R L QQ  S  Q S    Q   YQ  S     

M. musculus

   H         M    GE  H L QQ  S  Q T    Q   CR  S     

Human

   H         I    DQ  R M LE  R  R S    Q   YQ  M

Sry1

KRPFFQEAQR LKTLHREKYP NYK YQ P HRRV KVPQRSYTLQ REVASTKLYN

Sry2

 R       R  KTL            P

Sry3

 R       R  KTL            T                          

Sry3B1

 R       R  KTL            T                          

Sry3B

 R       R  KTL            T                          

Sry3C

 R       R  KTL            T                          

M.m

 R       R  K I L                                       

Human

W       K  QAM                                       

Sry1

LLQWDNNLHT IIYGQDWARA AHQSSKNQKS IYLQPVDIPT GYPLQQKQQH

Sry2

                                                   (--

Sry3

 

Sry3B1

 

Sry3B

 

Sry3C

 

Sry1

QQQQHVHLQQ QQQQQHQFH                                  

Sry2

----------)                                           

Sry3

      H                                               

Sry3B1

      M  [Q]                                          

Sry3B

      H  [Q]                                          

Sry3C

      H                                                

  1. Predicted amino acid sequence for each of the 6 copies of Sry found on the SHR Y chromosome compared to the amino acid sequence of Sry1. The HMG box (amino acids 5–73) is underlined and compared to Mus musculus and Human. Human (nm_003140.1) and mouse (nm_11564.1) sequences are from REFSEQ. Only differences are noted, (---) indicate amino acids that are deleted in Sry2, and [] indicate amino acids added in Sry3B and Sry3B1. Consensus rat sequence is in black and differences are bold.