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Table 4 Association analyses of the GHRH polymorphisms with carcass traits (CW and EMA) among Korean native cattle

From: Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meat in Korean cattle

Trait

Loci

Location

Genotype

P

P COR

P WY

Q SAM

   

C/C*

C/R*

R/R*

    

CW

-4241A>T

5'UTR

214(306.2 ± 32.5)

180(315.3 ± 33.1)

34(321.7 ± 36.4)

0.005

0.025

0.025

0.025

 

-3195T>A

Intron1

140(306.6 ± 35.1)

222(312.6 ± 32.5)

63(314.6 ± 30.8)

0.449

1

0.952

1

 

-618T>A

Intron1

217(311.9 ± 30.9)

183(310.6 ± 36.3)

27(309.9 ± 34.7)

0.859

1

0.995

0.859

 

+114C>A

Intron2

199(314.2 ± 34.5)

186(308.8 ± 31.9)

39(309.5 ± 35.7)

0.496

1

0.952

1

 

+2042A>G

Intron3

276(310.0 ± 35.2)

134(313.6 ± 29.6)

15(317.8 ± 29.1)

0.835

1

0.995

1

 

+2279C>T

Intron3

206(308.7 ± 32.4)

184(313.3 ± 32.8)

35(316.9 ± 40.9)

0.815

1

0.995

1

 

ht1

.

282(313.5 ± 33.1)

129(306.6 ± 34.0)

16(308.9 ± 34.2)

0.219

1

0.474

0.377

 

ht2

.

285(311.8 ± 33.9)

128(309.3 ± 32.1)

14(316.3 ± 36.9)

0.594

1

0.509

0.554

 

ht4

.

330(312.5 ± 32.5)

90(307.3 ± 37.3)

7(302.4 ± 20.1)

0.174

0.931

0.474

0.59

 

ht5

.

332(311.2 ± 34.0)

93(311.6 ± 32.0)

2(299.5 ± 29.0)

0.340

1

0.474

0.401

EMA

-4241A>T

5'UTR

214(74.1 ± 8.2)

180(75.7 ± 8.7)

34(78.2 ± 9.3)

0.009

0.046

0.064

0.066

 

-3195T>A

Intron1

140(75.2 ± 7.6)

222(75.0 ± 8.9)

63(75.6 ± 9.6)

0.583

1

0.991

1

 

-618T>A

Intron1

217(75.2 ± 8.2)

183(75.2 ± 9.1)

27(74.1 ± 7.7)

0.742

1

0.998

1

 

+114C>A

Intron2

199(75.1 ± 9.5)

186(75.0 ± 7.8)

39(75.3 ± 6.4)

0.945

1

0.998

0.95

 

+2042A>G

Intron3

276(75.1 ± 8.5)

134(75.1 ± 8.9)

15(76.8 ± 9.0)

0.799

1

0.998

1

 

+2279C>T

Intron3

206(74.3 ± 9.3)

184(75.6 ± 7.6)

35(77.5 ± 8.6)

0.920

1

0.998

1

 

ht1

.

282(75.2 ± 8.8)

129(75.0 ± 8.3)

16(76.1 ± 5.9)

0.716

1

0.713

0.671

 

ht2

.

285(75.6 ± 8.2)

128(74.3 ± 9.1)

14(74.3 ± 9.9)

0.402

1

0.574

0.486

 

ht4

.

330(75.7 ± 8.3)

90(73.7 ± 9.3)

7(68.3 ± 6.0)

0.022

0.12

0.088

0.089

 

ht5

.

332(75.2 ± 8.9)

93(74.9 ± 7.1)

2(76.0 ± 2.8)

0.316

1

0.528

0.572

  1. Genotype and haplotype distributions, means, standard deviations (SD), P values controlling for sire and age at slaughter as covariates was shown. *C/C, C/R, and R/R represent the common allele, heterozygotes and homozygotes for the rare allele, respectively. To achieve a simple correction for multiple testing of single-nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, the effective number of independent marker loci (5.35) in GHRH was calculated using the software SNPSpD [23], on the basis of the spectral decomposition (SpD) of matrices of pair-wise LD between SNPs [24]. PCORrepresents the simple corrected P value. The permutation based P values, PWYwere obtained by the Westfall and Young's method [25]. The FDR values QSAMwere estimated using the permutation test [26].