Figure 2

Gene-environment interaction. Top Panel: Gene environment interactions for SNP rs275649. Interaction test results for the six phenotypes by are presented for sex (men vs. women), age, body mass index, hypertension (yes vs. no), hypertension treatment (yes vs. no) and cigarette smoking (yes vs. no). Color coding of statistical significance levels is the same as presented in Figure 1. Asterisks designate cells with fewer than 10 observations in one of the phenotype-genotype subgroups. Bottom Panel: Mean values (and standard errors) for left ventricular wall thickness (LVWT) for SNP rs275649 by genotype and cigarette smoking status (nonsmokers in open bars, smokers in filled bars). Test for interaction yielded p < 0.0001. Data are adjusted for age and sex and clinical covariates. The cross hatched bar indicates a group with fewer than 10 subjects.