Multi-locus genotypes | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
|---|
Case | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.20 | 0.00 | 0.02 | 0.12 | 0.00 | 0.06 | 0.58 |
Control | 0.01 | 0.04 | 0.01 | 0.05 | 0.00 | 0.03 | 0.22 | 0.03 | 0.03 | 0.20 | 0.01 | 0.05 | 0.33 |
- Legend for Table 1. In this table we provide the generating frequencies in case and control populations for the thirteen multi-locus genotypes. We number the genotype frequencies 0 – 12. The multi-locus genotype corresponding to each coded genotype (0–12) is given under the heading "Genotype Codings" (see directly below). Note that, at each SNP, we use the code 1, 2, 3 to refer to the less common homozygote, heterozygote, and more common homozygote, respectively. For example, the code "3 : 3 : 3" is the multi-locus genotype consisting of the more common homozygote at each of the three SNP loci. Also note that these generating frequencies suggest a recessive mode of inheritance for AS in our simulations, since greatest risk occurs for individuals who are homozygous for each of the three SNPs (code 3 : 3 : 3).
- Genotype Codings:
- 0 = 1 : 2 : 2
- 1 = 1 : 3 : 3
- 2 = 2 : 1 : 1
- 3 = 2 : 2 : 2
- 4 = 2 : 2 : 3
- 5 = 2 : 3 : 2
- 6 = 2 : 3 : 3
- 7 = 3 : 1 : 1
- 8 = 3 : 2 : 1
- 9 = 3 : 2 : 2
- 10 = 3 : 3 : 1
- 11 = 3 : 3 : 2
- 12 = 3 : 3 : 3
