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Figure 5 | BMC Genetics

Figure 5

From: Spontaneous rescue from cystic fibrosis in a mouse model

Figure 5

Short-circuit current (Isc) measurements. delta Isc represents the change in short-circuit current from baseline after addition of either forskolin, genistein, carbachol, or amiloride. Upper panel. Bioelectric characteristics of the F28 CF/1-CftrTgH(neoim)Hgu(n = 4) and F27 CF/3-CftrTgH(neoim)Hgu(n = 4) in the ileum compared with those of wild type MF1 (n = 5) and C57BL/6J (n = 4) mice. *, significant p-values compared to MF-1. Lower panel. Bioelectric characteristics of the F28 CF/1-CftrTgH(neoim)Hguand F27 CF/3-CftrTgH(neoim)Hguin the nasal epithelium compared with those of wild type MF1 and C57BL/6J. The amiloride response is significantly increased in both CF/1-CftrTgH(neoim)Hguand CF/3-CftrTgH(neoim)Hgumice compared to MF1 wild type outbred mice. C57BL/6J inbred wild type mice exhibited less chloride secretion than MF1. The forskolin evoked chloride secretion in both CF/1-CftrTgH(neoim)HguCftrTgH(neoim)Hguand CF/3-CftrTgH(neoim)Hguwas reduced compared to wild type MF1 but elevated compared to wild type C57BL/6J inbred mice.

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