Skip to main content

Table 1 Summary of disease association results. Number of individuals in the sequencing panel, number of polymorphisms identified per gene, number of tag SNPs selected. Minor allele frequency cut-off used in tag SNP selection, minimum R2 of each set of tag SNPs, number of trios analysed, χ2 results and multilocus test P values for the IFNA gene cluster, IFNB1, IFNW1 and IFNG.

From: Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

  

Number of

     

SNP/Gene/Region

Individuals sequenced

Polymorphisms

Tag SNPs

MAF cut-off

Min R2

Trios

χ2

P

IFNA

32

77

20

0.1

0.81

1,335

21.9

0.35

IFNB1

32

11

4

0.05

0.83

1,427

7.2

0.12

IFNW1

32

22

10

0.05

0.88

1,401

4.9

0.90

IFNG

23

7

4

0.1

0.84

1,417

3.8

0.43

IFNG – rs2430561

-

-

-

-

-

1,157

2.9

0.091