A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms

Table 1 Comparisons of information content and NPL scores between 11,120 SNPs (All) and 7,328 SNPs (Subset) in genome-wide scans, regions with maximum NPL scores ≧ 1.5 were reported.

	Average information content		Peak NPL score		Position (cM)
Chr	All	Subset	All	Subset	All	Subset
1	0.91	0.91	1.81 ^a	1.75	77.15	77.15
			1.79	1.54	107.16	107.16
			1.56		126.23
			2.04	1.95	142.09	142.09
			2.13		237.83
			1.75	1.92	274.27	274.27
2	0.93	0.92	2.72		5.74
			2.44	2.33	18.03	18.03
			3.81		90.58
				3.72		90.60
			2.96	2.99	112.07	112.07
				1.98		135.497
			2.31		136.45
			2.74	2.59	244.44	244.44
3	0.93	0.91		1.70		60.44
			1.80		60.44
			1.84		86.23
				2.10		111.82
			1.88	2.13	143.25	144.53
4	0.92	0.92	2.86	2.59	204.47	204.47
5	0.92	0.92	1.52		109.78
6	0.89	0.89	2.06		21.02
			1.92	2.03	116.07	116.07
			2.03	1.74	185.42	185.42
7	0.91	0.92	1.98	1.74	13.65	13.65
				2.72		31.68
			2.86		31.84
			2.23		54.06
				1.96		54.08
			2.90	2.81	101.05	101.05
			1.98	2.04	123.79	123.79
			2.08		128.61
8	0.92	0.92	2.29	2.24	21.97	21.97
			2.10		41.70
				2.14		42.16
9	0.92	0.91	2.24	2.13	141.17	141.17
10	0.91	0.90		1.57		47.31
			1.71		48.75
			2.74	2.85	106.69	106.69
			2.03	1.87	128.63	128.63
			3.76	3.08	171.41	171.41
11	0.91	0.92		2.44		125.15
			2.94		125.27
12	0.92	0.91	1.58		4.76
			1.53		51.77
			1.88		71.83
			2.06	2.08	86.43	86.43
			1.71		107.48
				1.64		122.16
			1.60		122.20
			1.85		169.44
13	0.83	0.92	1.87		0.0000
			2.56	2.26	86.87	86.87
14	0.92	0.91	1.81	1.66	23.73	23.73
			1.71	1.66	88.50	88.50
15	0.91	0.91	1.62		29.81
16	0.90	0.89
17	0.90	0.89
18	0.92	0.91		2.19		106.82
			2.35		108.45
19	0.88	0.87
20	0.90	0.90		1.74		5.81
21	0.92	0.91
22	0.87	0.87	1.61	1.57	28.51	28.50
23	0.91	0.91	3.21	3.21	42.78	42.78
Overall average SD	0.91 (1.18)	0.91 (0.094)

^aGray text indicates local maximums in the region, while black text indicates the global maximum.

ISSN: 2730-6844