Comparison of the power between microsatellite and single-nucleotide polymorphism markers for linkage and linkage disequilibrium mapping of an electrophysiological phenotype

Table 2 Family-based SNP haplotype LD analysis

Haplotype	Frequency	z-score	p-value^a	2 SNPs
h1: 2 1	0.423	2.692	0.007094	Illumina's rs
h2: 1 2	0.416	-1.869	0.061690	1476640
h3: 2 2	0.156	-1.175	0.240070	rs768055
h4: 1 1	0.005	-0.761	0.446698	Distance = 741 bp
Global-test	DF = 3	χ² = 7.564	0.055929	D' = 0.98
Haplotype	Frequency	z-score	p-value	2 SNPs
h1: 2 1	0.438	-2.325	0.020064	Illumina's
h2: 1 2	0.371	3.060	0.002212	rs768055
h3: 2 2	0.135	-0.609	0.542501	rs1859646
h4: 1 1	0.056	-0.715	0.474386	Distance = 82,553 bp
Global-test	DF = 3	χ² = 9.494	0.023396	D' = 0.88
Haplotype	Frequency	z-score	p-value	3 SNPs
h1: 1 2 1	0.379	-2.060	0.039409	Illumina's rs1476640
h2: 2 1 2	0.367	3.064	0.002186	rs768055
h3: 2 2 2	0.095	-0.981	0.326434	rs1859646
h4: 2 2 1	0.060	-0.633	0.526774	Distance = 741 & 82,553 bp
h5: 2 1 1	0.054	-0.524	0.600176
h6: 1 2 2	0.039	0.217	0.828502
Others	0.005	/
Global-test	DF = 6	χ² = 10.352	0.110580
Haplotype	Frequency	z-score	p-value	2 SNPs
h1: 1 2	0.687	1.402	0.160879	Affymetrix's
h2: 2 1	0.235	-0.318	0.750300	tsc0058416
h3: 2 2	0.048	0.447	0.654974	tsc0058418
h4: 1 1	0.030	-3.456	0.000549	Distance = 148 bp
Global-test	DF = 3	χ² = 12.272	0.006509	D' = 0.98
Haplotype	Frequency	z-score	p-value	2 SNPs
h1: 1 2	0.851	3.097	0.001958	Affymetrix's
h2: 2 1	0.115	-1.537	0.124173	tsc0590615
h3: 1 1	0.033	-3.616	0.000300	tsc0590614
h4: 2 2	0.001	/		Distance = 14 bp
Global-test	DF = 2	χ² = 15.661	0.000397	D' = 1.00

ISSN: 2730-6844