Covariate linkage analysis of GAW14 simulated data incorporating subclinical phenotype, sex, population, parent-of-origin, and interaction

Table 2 Maximum LOD scores and number of parameters estimated for each covariate analysis on each chromosome

Covariate analysis^a	Number of parameters	Maximum LOD score for each chromosome^b
		1	2	3	4	5	6	7	8	9	10
A	3	8.00	3.07	8.67	2.31	10.05	2.31	2.03	2.56	8.77	1.35
B	3	14.29	3.00	8.26	1.93	4.91	2.71	2.87	1.49	9.76	1.67
c/d/g	3	8.11	2.67	8.45	1.82	6.50	2.44	1.71	2.60	8.75	5.31
e/f/h	3	7.07	2.03	7.49	0.52	4.90	1.53	0.71	0.59	7.65	1.04
I	3	7.72	2.20	8.41	1.64	7.34	2.62	1.33	2.07	8.45	1.51
J	3	7.22	2.94	7.73	2.83	6.97	3.37	1.28	1.74	9.30	1.57
K	3	7.35	2.69	9.43	2.38	5.46	2.24	2.11	2.77	18.13	1.33
L	3	7.53	2.61	9.38	2.01	5.25	2.01	1.28	1.58	9.92	1.65
Sex	3	7.30	4.18	7.67	2.26	5.40	1.81	1.26	1.74	8.01	2.09
Population	4	8.55	3.89	7.73	1.62	5.72	2.67	2.49	1.88	9.25	3.42
Univariate (ARP)	1	7.07	2.03	7.49	0.52	4.90	1.53	0.71	0.59	7.65	1.04
Parent-of-origin (ASP)	2	5.77	2.42	8.05	0.57	3.90	2.31	1.88	1.21	7.48	2.00
Univariate (ASP)	1	4.84	1.75	7.14	0.41	3.75	2.29	0.62	0.45	7.35	1.67

^a All analyses, except for parent-of-origin, were based on affected relative pairs (ARP). Parent-of-origin was an affected sibling pair (ASP) analysis.
^b The LOD scores marked in bold indicate the analyses that showed an increase in maximum LOD score from the baseline univariate to the covariate LOD that reached genome-wide significance. Chromosome 10, subclinical phenotype c/d/g was genome-wide significant at p = 0.063 and has also been indicated in bold.

ISSN: 2730-6844