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Table 1 MOD scores and estimated trait-model parameters for microsatellites and SNPsa

From: Linkage analysis of alcohol dependence using MOD scores

   

Penetrancesc

 

Chromosome

Positionb

MOD

 

f +/+

f m/+

f +/m

f m/m

p

Microsatellites

1

140.3

5.93

Male

0.0080

0.0100

0.0080

0.1000

0.050

 

D1S1631

 

Female

0.1000

0.9500

0.9500

0.9500

 

2

135.9

4.34

Male

0.0450

0.0600

0.0450

0.4900

0.008

 

D2S1328

 

Female

0.0350

0.3900

1.0000

1.0000

 

7

20.7

2.94

Male

0.0450

0.1000

0.0450

0.2500

0.010

 

D7S1790

 

Female

0.0500

0.5400

0.0500

1.0000

 

7

122.3

2.46

Male

0.0008

0.0020

0.0008

0.0080

0.500

 

D7S1799

 

Female

0.0000

0.0000

0.0000

0.3400

 

10

61.3

3.73

Male

0.0000

0.5500

0.5100

1.0000

0.240

 

D10S1426

 

Female

0.0000

0.0000

0.1600

0.1600

 

12

171.6

3.68

Male

0.0600

0.1500

0.2100

0.2300

0.020

 

D12S1045

 

Female

0.1300

0.5100

1.0000

1.0000

 

13

37.6

2.73

Male

0.0050

0.0050

0.0100

0.0100

4·10-5

 

D13S325

 

Female

0.0150

0.1800

0.6600

1.0000

 

15

126.6

3.67

Male

0.0080

0.0080

0.0100

0.0100

0.920

 

D15S642

 

Female

0.1100

0.1100

1.0000

1.0000

 

21

38.0

3.86

Male

0.0000

0.0500

0.0900

0.0900

0.390

 

D21S1440

 

Female

0.0000

0.0000

0.1000

0.7400

 

Affymetrix SNPs

1

150.0

4.10

Male

0.0500

0.0500

0.0500

0.3600

0.080

 

tsc0056040

 

Female

0.0500

0.5600

0.8300

0.8300

 

2

147.2

3.26

Male

0.0450

0.1100

0.0450

0.2700

0.110

 

tsc1376918

 

Female

0.1600

0.4300

1.0000

1.0000

 

7

18.3

3.66

Male

0.0250

0.1000

0.0800

0.1300

0.210

 

tsc0058614

 

Female

0.0000

0.0150

0.0150

0.1100

 

7

99.2

3.46

Male

0.0000

0.0200

0.0000

0.0500

0.490

 

tsc0287517

 

Female

0.0000

0.7400

0.0000

0.7400

 

10

62.9

4.24

Male

0.0000

0.0700

0.0700

0.1100

0.470

 

tsc0608195

 

Female

0.0350

0.0350

0.8700

0.8700

 

12

156.1

2.61

Male

0.0450

0.0900

0.0450

0.6000

0.010

 

tsc0053128

 

Female

0.0800

0.0800

0.5800

1.0000

 

13

62.0

3.97

Male

0.0500

0.0600

0.1100

0.1300

0.110

 

tsc0949707

 

Female

0.1500

0.1500

1.0000

1.0000

 

15

 

---d

      

21

 

---d

      
  1. a Genetic regions for which the analysis allowing for imprinting yielded a MOD score around or above 3.5 either for the microsatellites (sex-specific map) or the Affymetrix SNPs (sex-averaged map), together with the best-fitting parameters of the trait model.
  2. b The genetic positions of the highest MOD (given in cM, together with the marker closest to the peak) reflect different coordinates for the COGA microsatellite and Affymetrix SNP maps. Therefore, two results given at corresponding positions in the table for microsatellite and SNP markers most likely reflect the same linkage signal, despite possibly different genetic positions for the two marker sets.
  3. c +, the wild-type; m, mutant allele, with the paternally inherited allele listed first; p, the disease allele frequency. A trait model with fm/+»f+/m points to maternal imprinting (i.e., paternal expression), whereas fm/+«f+/mindicates paternal imprinting (i.e., maternal expression).
  4. d ---, In the two genetic regions on chromosomes 15 and 21 mentioned for the microsatellites, MOD scores were below 2 for the Affymetrix SNPs.
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BMC Genomic Data

ISSN: 2730-6844

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