Table 1 OSA analysis using peak locations on chromosomes with disease loci as covariates
From: Searching for epistatic interactions in nuclear families using conditional linkage analysis
Chromosome | Â | Â | Â | Â | Â | Â | Proportion of replicates w/empirical p-values less than | ||
|---|---|---|---|---|---|---|---|---|---|
Analysis (locus) | Covariate (cM) | OSA LOD [Mean (SD)] | Delta LODa [Mean (SD)] | Proportion of families in OSA subset [Mean (SD) | OSA analysis chromosome position (cM) [Mean (SD)] | Position of Siblink max LOD score (cM) [Mean (SD)] | True position (cM)b | 0.01 | 0.05 |
1 (D1) | 3 (297) c | 7.4 (2.7) | 0.4 (0.5) | 0.93 (0.11) | 168.0 (3.9) | 167.8 (4.3) | 167.9 | 0 | 0.03 |
| Â | 9 (6) | 7.6 (2.7) | 0.5 (0.7) | 0.92 (0.16) | 164.8 (23.0) | Â | Â | 0.01 | 0.04 |
2 (D6) | 5 (6) | 1.9 (0.6) | 1.4 (0.7) | 0.28 (0.30) | 163.2 (91.2) | 143.2 (9.0) | 14.8 | 0.01 | 0.04 |
| Â | 9 (6) | 1.9 (0.6) | 1.5 (0.7) | 0.28 (0.31) | 149.5 (86.9) | Â | Â | 0 | 0.01 |
3 (D2) | 2 (15) | 8.2 (2.5) | 0.4 (0.5) | 0.92 (0.12) | 297.0 (1.7) | 296.4 (1.6) | 297.7 | 0.01 | 0.05 |
| Â | 5 (6) | 8.3 (2.6) | 0.5 (0.6) | 0.92 (0.13) | 297.1 (1.7) | Â | Â | 0.01 | 0.08 |
4 | 3 (297) | 1.8 (0.6) | 1.3 (0.7) | 0.38 (0.29) | 165.7 (86.5) | Â | N/A | 0.03 | 0.05 |
| Â | 5 (6) | 1.9 (0.6) | 1.4 (0.8) | 0.26 (0.29) | 144.5 (85.6) | Â | Â | 0.03 | 0.07 |
5 (D3) | 2 (15) | 4.7 (1.8) | 0.7 (0.8) | 0.79 (0.29) | 15.3 (39.9) | 7.9 (21.6) | 6 | 0.01 | 0.04 |
| Â | 3 (297) | 4.6 (1.8) | 0.6 (0.7) | 0.80 (0.26) | 12.3 (34.9) | Â | Â | 0.01 | 0.07 |
6 | 3 (297) | 1.8 (0.7) | 1.2 (0.7) | 0.34 (0.31) | 165.7 (93.2) | Â | N/A | 0 | 0.03 |
| Â | 5 (6) | 2.0 (0.9) | 1.8 (0.9) | 0.20 (0.23) | 166.1 (92.7) | Â | Â | 0 | 0.03 |
9 (D4) | 1 (168) | 4.5 (2.0) | 0.7 (0.8) | 0.79 (0.31) | 27.0 (62.7) | 13.9 (42) | 5.6 | 0 | 0.02 |
| Â | 5 (6) | 4.6 (2.0) | 0.8 (0.9) | 0.76 (0.31) | 38.0 (78.7) | Â | Â | 0.01 | 0.03 |
10 (D5) | 3 (297) | 1.8 (0.7) | 1.1 (0.7) | 0.41 (0.34) | 81.4 (55.2) | 82.4 (53.6) | 67 | 0 | 0.02 |
| Â | 5 (6) | 2.0 (0.9) | 1.4 (0.8) | 0.28 (0.31) | 88. 1 (50.9) | Â | Â | 0.03 | 0.07 |