Analysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage

BMC Genomic Data

Table 1 Most significant peaks for LODPAL, OSA, and pre-cluster

Chr	Position (cM)	Locus	Covariate	Linked cluster/subset and size^a	LOD score	-log₁₀ (p-value)
LODPAL
3	160.00	ATA34G06		NA	4.72	>4.48
4	61.00	GABRB1	ecb21	NA	6.61	>4.48
12	187.00	D12S1045	ttth1	NA	4.26	>4.48
OSA
4	p-ter	D4S2366	ttth1	H2L [42 out of 156 ]	2.48	2.44
7	62.19	D7S2846	Age of onset	H2L [35 out of 156]	3.09	3.30
10	148.19	D10S544	ttth1	H2L [41 out of 156]	3.40	3.32
Pre-cluster
10	194.37	D10S590	ecb21	G2 [101 out of 142]	2.10	2.89
11	90.91	D11S2002	ttth1	G1 [36 out of 133]	1.90	2.68
21	73.68	D21S1446	ecb21	G2 [108 out of 149]	1.86	2.62
GENEHUNTER-PLUS
10	148.19	D10S544	NA	NA	2.86	>4.48

^aThe numbers within square brackets in the "Linked cluster/subset" column represent the cluster or subset size in terms of ASPs for pre-cluster and pedigrees for OSA.

ISSN: 2730-6844