Skip to main content

Table 3 Age at diagnosis in retinoblastoma patients according to phenotype and type of mutation. Statistical analysis using the Welch's unpaired t test.

From: RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database

Phenotype Frameshift Nonsense Missense Splicing SP vs. NS-MS-FS
Unilateral 21.1 26.0 23.7 26.7 P = 0.7237
Bilateral 9.5 11.8 9.4 19.3 P = 0.0025
All 12.4 15.6 16.0 21.8 P = 0.0044
Unilateral vs. Bilateral P = 0.0073 P = 0.0147   P = 0.3321