Figure 2
Schematic picture of the exon/intron structure of the A4GALT ( Pk) gene and the positions of the 19 polymorphisms investigated. The numbering systems used are as follows: The 5'-region and exon 1 are described using the same numbering as Iwamura et al. [15] for easy comparison. Intron 1 and exon 2 are numbered from the first nucleotide of each element, with the number being preceded by int1- or ex2-, respectively. The adenosine of the translation start codon ATG in exon 3 is defined as nt. 1. Nucleotides upstream from this (untranslated exon 3 and the 3'-region of intron 2) are given as negative numbers. The exons are represented by rectangles and the intervening introns by triangles. Exons 1–3 are 21, 145 and 1059 bp long, respectively and introns 1 and 2 are approximately 25 and 1.5 kbp long, respectively.