Figure 7

Tail cuff blood pressure in male and female F2 rats with time. Tail cuff measured blood pressures for male F2 rats (panel A) and female F2 rats (panel B) were monitored with time and analyzed by genotype (solid squares, WT; solid diamonds, HET and solid triangles, HMZ). No significant differences were noted between any of these genotypes. For comparison, the average blood pressures of rats at age 16 weeks for SD and SHR were 127 mm Hg and 197 mm Hg respectively. Additionally, female rats at 17 weeks were placed on a defined sitosterol diet and fed 1% NaCl drinking water (see bar, panel B). Neither significant increases in blood pressures, nor any differences between the genotypes were observed.