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Table 2 Genotype frequency of two MLPH polymorphisms in different breeds

From: Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

Breed and phenotype No. of animals dilute genotype1 Exon 22 Exon 7
    CC3 CT TT 199R199R 199R199H 199H199H
Doberman Pinscher (all) 140   50 (36%) 69 (49%) 21 (15%) 82 (59%) 47 (34%) 11 (8%)
   wildtype coat color 98 D. 50 (51%) 48 (49%) - 62 (63%) 33 (34%) 3 (3%)
   wildtype coat color 21 Dd - 21 (100%) - 9 (43%) 12 (57%) -
   dilute coat color 21 dd - - 21 (100%) 11 (52%) 2 (10%) 8 (38%)
Doberman Pinscher (American origin) 38   6 (16%) 21 (55%) 11 (29%) 35 (92%) 3 (8%) -
   wildtype coat color 19 D. 6 (32%) 13 (68%) - 16 (84%) 3 (16%) -
   wildtype coat color 8 Dd - 8 (100%) - 8 (100%) - -
   dilute coat color 11 dd - - 11 (100%) 11 (100%) - -
Doberman Pinscher (European origin) 102   44 (43%) 48 (47%) 10 (10%)    
   wildtype coat color 79 D. 44 (56%) 35 (44%) - 46 (58%) 30 (38%) 3 (4%)
   wildtype coat color 13 Dd - 13 (100%) - 1 (8%) 12 (92%) -
   dilute coat color 10 dd - - 10 (100%) - 2 (20%) 8 (80%)
German Pinscher 143   143 (100%) - - 64 (45%) 61 (43%) 18 (13%)
   wildtype coat color 117 D. 117 (100%) - - 64 (55%) 53 (45%) -
   wildtype coat color 8 Dd 8 (100%) - - - 8 (100%) -
   dilute coat color 18 dd 18 (100%) - - - - 18 (100%)
Beagle 6   1 3 2 1 3 2
   wildtype coat color 2 D. 1 1   1 1  
   wildtype coat color 2 Dd   2    2  
   dilute coat color 2 dd    2    2
Large Munsterlander 12   - 8 4 - 7 5
   wildtype coat color 8 Dd - 8 - - 7 1
   dilute coat color & BHFD 4 dd - - 4 - - 4
Weimeraner (dilute coat color) 1 dd   1    1  
Am. Staffordshire (dilute col. & CDA) 1 dd   1    1  
Mountain Dogs 26 D. 25 1   25 1  
Breeds unspecified 12 D. 10 2   9 3  
total 341   229 (67%) 85 (25%) 27 (8%) 181 (53%) 124 (36%) 36 (11%)
  1. 1 A dog with wildtype coat color has the dilute genotype DD or Dd. If the animal has never produced any dilute (dd) offspring, the genotype can not be deduced unambiguously from the phenotype and the genotype is then denoted "D.". Among the Pinschers with wildtype coat colors there were also obligate carriers of the dilute allele (Dd), as these animals had dilute (dd) progeny.
  2. 2 This polymorphism corresponds to the silent C/T SNP in exon 2 at position 164258 in the reference sequence [EMBL:BN000728].
  3. 3 The following associations were highly significant in Pinscher breeds under Fisher's Exact Test (p < 0.001): Exon 2 for all Doberman Pinschers, American Doberman Pinschers, and European Doberman Pinschers; exon 7 for European Doberman Pinschers and for German Pinschers. Non-Pinscher breeds were not evaluated statistically because of their small sample numbers.