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Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.

From: Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10

  B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 240 201 57 52
+/- 431 403 115 104
-/- 134 201 36 52
P <0.00001 (0.01612)*   0.03749  
  1. Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes.