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Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.

From: Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10

 

B6 Background

Mixed Background

Cftr

Observed

Expected

Observed

Expected

+/+

207

175

57

47

+/-

371

350

88

94

-/-

122

175

42

47

P

0.00001 (0.04533)*

 

0.21724

 
  1. Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes.