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Table 4 Power to detect an association for two susceptibility sites simulated under model 3

From: On the use of haplotype phylogeny to detect disease susceptibility loci

   Model 3  
Tree CT CLADHC HT SbST
1 40.7 (4.7) 54.0 (4.5) 42.0 (5.9) 47.5 (4.7)
2 31.7 (3.4) 32.7 (3.9) 43.0 (5.9) 45.8 (5.3)
3 26.8 (4.2) 47.9 (4.4) 40.7 (6.4) 45.2 (3.5)
4 34.8 (4.8) 39.2 (4.7) 38.9 (7.0) 47.0 (4.4)
5 41.5 (5.6) 49.7 (4.7) 44.2 (6.6) 37.2 (4.6)
6 42.0 (3.6) 34.8 (4.7) 42.4 (5.6) 41.3 (5.3)
7 28.6 (5.2) 32.1 (4.7) 41.6 (6.4) 39.9 (4.3)
8 33.2 (4.3) 47.2 (4.0) 42.9 (6.1) 37.7 (4.0)
9 33.5 (4.4) 39.1 (4.1) 41.2 (7.0) 48.5 (5.3)
10 65.6 (6.6) 48.1 (4.1) 42.1 (7.8) 56.9 (4.2)
Average 37.84 (4.7) 42.48 (4.4) 41.9 (6.5) 44.7 (4.6)
Std dev.a 11.07 (0.9) 7.84 (0.3) 1.45 (0.7) 5.94 (0.6)
  1. Sample size: 200 cases and 200 controls, 1000 replicates, penetrance: 0.6 for the homozygotes carrying the two susceptibility alleles, 0.3 for the other genotypes. The corresponding type I errors are indicated in italics within brackets. For each tree, the method giving the best result is underlined. CT: Cladistic Test, CLADHC: test developed by Durrant et al. [29], HT: Haplotypic Test, SbST: Site by Site Test
  2. a Standard deviation