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Table 4 Power to detect an association for two susceptibility sites simulated under model 3

From: On the use of haplotype phylogeny to detect disease susceptibility loci

  

Model 3

 

Tree

CT

CLADHC

HT

SbST

1

40.7 (4.7)

54.0 (4.5)

42.0 (5.9)

47.5 (4.7)

2

31.7 (3.4)

32.7 (3.9)

43.0 (5.9)

45.8 (5.3)

3

26.8 (4.2)

47.9 (4.4)

40.7 (6.4)

45.2 (3.5)

4

34.8 (4.8)

39.2 (4.7)

38.9 (7.0)

47.0 (4.4)

5

41.5 (5.6)

49.7 (4.7)

44.2 (6.6)

37.2 (4.6)

6

42.0 (3.6)

34.8 (4.7)

42.4 (5.6)

41.3 (5.3)

7

28.6 (5.2)

32.1 (4.7)

41.6 (6.4)

39.9 (4.3)

8

33.2 (4.3)

47.2 (4.0)

42.9 (6.1)

37.7 (4.0)

9

33.5 (4.4)

39.1 (4.1)

41.2 (7.0)

48.5 (5.3)

10

65.6 (6.6)

48.1 (4.1)

42.1 (7.8)

56.9 (4.2)

Average

37.84 (4.7)

42.48 (4.4)

41.9 (6.5)

44.7 (4.6)

Std dev.a

11.07 (0.9)

7.84 (0.3)

1.45 (0.7)

5.94 (0.6)

  1. Sample size: 200 cases and 200 controls, 1000 replicates, penetrance: 0.6 for the homozygotes carrying the two susceptibility alleles, 0.3 for the other genotypes. The corresponding type I errors are indicated in italics within brackets. For each tree, the method giving the best result is underlined. CT: Cladistic Test, CLADHC: test developed by Durrant et al. [29], HT: Haplotypic Test, SbST: Site by Site Test
  2. a Standard deviation