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Table 2 Power to detect an association, one susceptibility site simulated and removed from the analysis

From: On the use of haplotype phylogeny to detect disease susceptibility loci

Tree CT CLADHC HT SbST
1 94.8 (3.8) 89.1 (3.5) 91.2 (5.6) 89.5 (3.9)
2 94.0 (3.8) 92.7 (4.1) 87.6 (5.6) 98.5 (5.3)
3 79.3 (3.2) 88.9 (4.7) 86.2 (4.7) 94.2 (4.1)
4 88.7 (2.3) 85.7 (3.1) 87.8 (4.6) 93.6 (4.4)
5 85.6 (4.3) 94.4 (4.1) 90.5 (4.5) 94.0 (4.1)
6 78.6 (3.0) 81.6 (3.3) 88.0 (4.2) 67.0 (4.2)
7 92.4 (3.8) 90.5 (3.7) 87.8 (5.2) 92.7 (4.0)
8 99.7 (3.0) 98.6 (2.8) 91.2 (4.7) 99.6 (4.5)
9 91.9 (3.7) 89.2 (4.5) 91.2 (4.8) 89.1 (4.1)
10 88.8 (2.9) 82.8 (3.0) 81.3 (4.1) 79.1 (3.5)
Average 89,38 (3.4) 89.35 (3.7) 88,28 (4.8) 89,73 (4.2)
Std dev.a 6.71 (0.6) 5.2 (0.6) 3.06 (0.5) 9.81 (0.5)
  1. Sample size: 100 cases and 100 controls, 1000 replicates, penetrance vector: [0.03;0.06;0.3], frequency of the susceptibility allele: 0.205 ± 0.005. The corresponding type I errors are indicated in italics within brackets. For each tree, the method giving the best result is underlined. CT: Cladistic Test, CLADHC: test developed by Durrant et al. [29], HT: Haplotypic Test, SbST: Site by Site Test.
  2. a Standard deviation