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Table 1 Power to detect an association, one susceptibility site simulated and included in the analysis

From: On the use of haplotype phylogeny to detect disease susceptibility loci

Tree CT CLADHC HT SbST
1 96.4 (3.3) 88.9 (3.3) 91.1 (5.1) 99.3 (3.4)
2 99.0 (4.4) 95.7 (4.1) 91.3 (6.0) 99.5 (5.3)
3 86.0 (2.5) 91.1 (4.7) 91.2 (4.6) 99.3 (4.4)
4 96.3 (3.8) 95.6 (2.9) 91.5 (4.2) 99.3 (4.6)
5 88.8 (4.1) 95.3 (3.3) 90.4 (4.7) 99.1 (4.6)
6 84.5 (3.5) 88.8 (2.7) 90.7 (4.4) 99.5 (4.4)
7 97.4 (4.0) 96.3 (3.7) 91.9 (4.8) 99.2 (4.3)
8 99.7 (3.2) 98.5 (2.4) 91.2 (4.9) 99.4 (4.7)
9 88.1 (3.5) 94.0 (4.4) 91.3 (4.7) 99.4 (4.3)
10 92.5 (2.6) 93.0 (2.9) 91.3 (4.7) 99.5 (3.6)
Average 92.9 (3.5) 93.7 (3.4) 91.2 (4.8) 99.35 (4.4)
Std dev.a 5.63 (0.62) 3.24 (0.76) 0.41 (0.49) 0.13 (0.54)
  1. Sample size: 100 cases and 100 controls, 1000 replicates, penetrance vector: [0.03;0.06;0.3], frequency of the susceptibility allele: 0.205 ± 0.005. The corresponding type I errors are indicated in italics within brackets. For each tree, the method giving the best result is underlined. CT: Cladistic Test, CLADHC: test developed by Durrant et al. [29], HT: Haplotypic Test, SbST: Site by Site Test.
  2. a Standard deviation