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Table 1 Power to detect an association, one susceptibility site simulated and included in the analysis

From: On the use of haplotype phylogeny to detect disease susceptibility loci

Tree

CT

CLADHC

HT

SbST

1

96.4 (3.3)

88.9 (3.3)

91.1 (5.1)

99.3 (3.4)

2

99.0 (4.4)

95.7 (4.1)

91.3 (6.0)

99.5 (5.3)

3

86.0 (2.5)

91.1 (4.7)

91.2 (4.6)

99.3 (4.4)

4

96.3 (3.8)

95.6 (2.9)

91.5 (4.2)

99.3 (4.6)

5

88.8 (4.1)

95.3 (3.3)

90.4 (4.7)

99.1 (4.6)

6

84.5 (3.5)

88.8 (2.7)

90.7 (4.4)

99.5 (4.4)

7

97.4 (4.0)

96.3 (3.7)

91.9 (4.8)

99.2 (4.3)

8

99.7 (3.2)

98.5 (2.4)

91.2 (4.9)

99.4 (4.7)

9

88.1 (3.5)

94.0 (4.4)

91.3 (4.7)

99.4 (4.3)

10

92.5 (2.6)

93.0 (2.9)

91.3 (4.7)

99.5 (3.6)

Average

92.9 (3.5)

93.7 (3.4)

91.2 (4.8)

99.35 (4.4)

Std dev.a

5.63 (0.62)

3.24 (0.76)

0.41 (0.49)

0.13 (0.54)

  1. Sample size: 100 cases and 100 controls, 1000 replicates, penetrance vector: [0.03;0.06;0.3], frequency of the susceptibility allele: 0.205 ± 0.005. The corresponding type I errors are indicated in italics within brackets. For each tree, the method giving the best result is underlined. CT: Cladistic Test, CLADHC: test developed by Durrant et al. [29], HT: Haplotypic Test, SbST: Site by Site Test.
  2. a Standard deviation