TY - JOUR AU - Zeggini, Eleftheria AU - Barton, Anne AU - Eyre, Stephen AU - Ward, Daniel AU - Ollier, William AU - Worthington, Jane AU - John, Sally PY - 2005 DA - 2005/04/25 TI - Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition JO - BMC Genetics SP - 21 VL - 6 IS - 1 AB - The selection of markers in association studies can be informed through the use of haplotype blocks. Recent reports have determined the genomic architecture of chromosomal segments through different haplotype block definitions based on linkage disequilibrium (LD) measures or haplotype diversity criteria. The relative applicability of distinct block definitions to association studies, however, remains unclear. We compared different block definitions in 6.1 Mb of chromosome 17q in 189 unrelated healthy individuals. Using 137 single nucleotide polymorphisms (SNPs), at a median spacing of 15.5 kb, we constructed haplotype block maps using published methods and additional methods we have developed. Haplotype tagging SNPs (htSNPs) were identified for each map. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-6-21 DO - 10.1186/1471-2156-6-21 ID - Zeggini2005 ER -