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Table 1 Alleles and genotype distributions for five CART SNPs in 368 French non-obese group and in different French morbid obese groups.

From: Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

SNPs

allelesa

p-valueb

OR [95%CI]

genotypesa

p-valuec

-3608 T >C

T

C

  

TT

TC

CC

 

French non-obese subjects

311 (42.3)

425 (57.7)

  

51 (13.9)

209 (56.8)

108 (29.3)

 

1st set of French morbid obese subjects

299 (51.4)

283 (48.6)

0.001

1.44 [1.16–1.80]

78 (26.8)

143 (49.1)

70 (24.1)

0.0006

2nd set of French morbid obese subjects

287 (47.5)

317 (52.5)

0.05

1.24 [1.00–1.54]

65 (21.5)

157 (52.0)

80 (26.5)

0.04

Pooled set of French morbid obese subjects*

586 (49.4)

600 (50.6)

0.002

1.33 [1.11–1.61]

143 (24.1)

300 (50.6)

150 (25.3)

0.001

-3607 C >T

C

T

  

CC

CT

TT

 

French non-obese subjects

392 (53.3)

344 (46.7)

  

90 (24.5)

212 (57.6)

66 (17.9)

 

1st set of French morbid obese subjects

342 (58.8)

240 (41.2)

0.046

1.33 [1.11–1.61]

102 (35.1)

138 (47.4)

51 (17.5)

0.037

2nd set of French morbid obese subjects

346 (57.1)

260 (42.9)

0.16

1.17 [0.94–1.45]

100 (33.0)

146 (48.2)

57 (18.8)

0.14

Pooled set of French morbid obese subjects

688 (57.9)

500 (42.1)

0.046

1.21 [1.004–1.45]

202 (34.0)

284 (47.8)

108 (18.2)

0.04

-1702C> T

C

T

  

CC

CT

TT

 

French non-obese subjects

438 (63.3)

254 (36.7)

  

125 (36.1)

188 (54.3)

33 (9.6)

 

1st set of French morbid obese subjects

306 (54.4)

256 (45.6)

0.0015

1.44 [1.15–1.81]

82 (29.2)

142 (50.5)

57 (20.3)

0.0009

2nd set of French morbid obese subjects

345 (57.7)

253 (42.3)

0.04

1.27 [1.01–1.58]

94 (31.4)

157 (52.5)

48 (16.1)

0.028

Pooled set of French morbid obese subjects

651 (56.1)

509 (43.9)

0.002

1.35 [1.11–1.64]

176 (30.3)

299 (51.6)

105 (18.1)

0.0015

-175 A >G

A

G

  

AA

AG

GG

 

French non-obese subjects

294 (42.4)

400 (57.6)

  

48 (13.8)

198 (57.1)

101 (29.1)

 

1st set of French morbid obese subjects

279 (51.1)

267 (48.9)

0.0022

1.42 [1.13–1.78]

72 (26.4)

135 (49.4)

66 (24.2)

0.0014

2nd set of French morbid obese subjects

289 (46.8)

329 (53.2)

0.10

1.19 [0.96–1.49]

69 (22.3)

151 (48.9)

89 (28.8)

0.095

Pooled set of French morbid obese subjects

568 (48.8)

596 (51.2)

0.007

1.30 [1.07–1.57]

141 (24.2)

286 (49.1)

155 (26.7)

0.006

+1343 delA

A

delA

  

AA

AdelA

delAdelA

 

French non-obese subjects

656 (92.7)

52 (7.3)

  

304 (85.9)

48 (13.6)

2 (0.5)

 

1st set of French morbid obese subjects

520 (89.1)

64 (10.9)

0.02

1.53 [1.06–2.28]

232 (79.4)

56 (19.2)

4 (1.4)

0.02

2nd set of French morbid obese subjects

590 (89.6)

68 (10.4)

0.05

1.45 [1.00–2.12]

263 (80.0)

64 (19.4)

2 (0.6)

0.048

Pooled set of French morbid obese subjects

1110 (89.4)

132 (10.6)

0.017

1.50 [1.07–2.10]

495 (79.7)

120 (19.3)

6 (1.0)

0.017

  1. aNumber of alleles or genotypes (frequencies, %)
  2. b p-value corresponds to association analysis between different French morbidly obese groups (BMI ≥ 40 kg/m2) and non-obese subjects (BMI<27 kg/m2).
  3. c p-value is calculated by the Armitage's trend test.
  4. "Risk" alleles underlined are those encountered more frequently in obese groups.
  5. * Pooled set of 621 French morbidly obese subjects were composed of the first set of 292 French morbidly obese patients (BMI = 47.5 ± 7.8 kg/m2, age = 44.7 ± 10.8 years) and of a second set of 329 French morbidly obese patients (BMI = 48.1 ± 7.1 kg/m2, age = 48.5 ± 10.5 years).
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BMC Genomic Data

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