|
K
|
R*
|
p
|
C
θ
|
C
φ
|
|---|
|
0.005
|
0.5
|
0.05
|
0.01
|
540.29
|
| | |
0.15
|
0.01
|
458.99
|
| |
1
|
0.05
|
0.01
|
478.32
|
| | |
0.15
|
0.01
|
432.67
|
| |
2
|
0.05
|
0.01
|
440.18
|
| | |
0.15
|
0.01
|
415.60
|
|
0.05
|
0.5
|
0.05
|
0.09
|
51.59
|
| | |
0.15
|
0.10
|
43.82
|
| |
1
|
0.05
|
0.08
|
45.67
|
| | |
0.15
|
0.10
|
41.31
|
| |
2
|
0.05
|
0.08
|
42.03
|
| | |
0.15
|
0.10
|
39.68
|
- The column heading for this table are as follows: K = prevalence; R* = ratio of controls to cases; p = SNP minor allele frequency in affected population; C
θ
= Cost coefficient corresponding to misclassification parameter θ – this is a lower bound of the percent increase in sample size necessary to maintain constant asymptotic power for every 1% increase in θ C
φ
= Cost coefficient corresponding to misclassification parameter φ – this is a lower bound of the percent increase in sample size necessary to maintain constant asymptotic power for every 1% increase in φ. The cost coefficients are computed using equation (1).
