K
| R* |
p
|
C
θ
|
C
φ
|
|---|
0.005 | 0.5 | 0.05 | 0.01 | 540.29 |
| Â | Â | 0.15 | 0.01 | 458.99 |
| Â | 1 | 0.05 | 0.01 | 478.32 |
| Â | Â | 0.15 | 0.01 | 432.67 |
| Â | 2 | 0.05 | 0.01 | 440.18 |
| Â | Â | 0.15 | 0.01 | 415.60 |
0.05 | 0.5 | 0.05 | 0.09 | 51.59 |
| Â | Â | 0.15 | 0.10 | 43.82 |
| Â | 1 | 0.05 | 0.08 | 45.67 |
| Â | Â | 0.15 | 0.10 | 41.31 |
| Â | 2 | 0.05 | 0.08 | 42.03 |
| Â | Â | 0.15 | 0.10 | 39.68 |
- The column heading for this table are as follows: K = prevalence; R* = ratio of controls to cases; p = SNP minor allele frequency in affected population; C
θ
= Cost coefficient corresponding to misclassification parameter θ – this is a lower bound of the percent increase in sample size necessary to maintain constant asymptotic power for every 1% increase in θ C
φ
= Cost coefficient corresponding to misclassification parameter φ – this is a lower bound of the percent increase in sample size necessary to maintain constant asymptotic power for every 1% increase in φ. The cost coefficients are computed using equation (1).
