| |
Low
|
High
|
|---|
|
True case and control genotype frequencies
|
p = 0.05
|
p = 0.15
|
|
Pr(affected misclassified as a control) (θ)
|
0.05
|
0.15
|
|
Pr(unaffected misclassified as a case) (φ)
|
0.05
|
0.15
|
|
Disease prevalence (K)
|
0.005
|
0.05
|
Number of cases ( )
|
500
|
1000
|
Number of controls ( )
|
500
|
1000
|
|
Significance level
|
5%
|
1%
|
|
Genotype frequency parameter for tetra-allelic loci (power simulations)
| | |
|
d
|
1
|
2
|
- This table presents the low and high parameter settings we consider for null and power simulation calculations for di-allelic and tetra-allelic loci. As per the 27 factorial design, null and power simulations are performed on 128 distinct sets of parameter settings. Each simulation uses 100,000 iterations to determine empirical significance level (null) or simulation power. For di-allelic loci, case and control genotype frequencies are determined by the parameter p (see Methods – design of simulation program – power calculations for a fixed sample size). For tetra-allelic loci, genotype frequencies are determined by the parameter d (see Methods – Design of simulation program – power calculations for a fixed sample size).
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