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Figure 3 | BMC Genetics

Figure 3

From: Increasing incidence of Type 1 diabetes – role for genes?

Figure 3

Predicted curves for disease incidence (/100,000/year) of a population experiencing transmission distortion as a function of allele frequency, where for homozygote AA the penetrance is λ AA = 160 and λ aa = 10. Four models of gene expression were explored ('A' dominant to 'a' (---), alleles codominant (-- --), allele effects multiplicative (-- ··· --), and 'A' recessive to 'a' (·········)). The penetrance for heterozygous genotype is always between (or equal to) those of homozygotes.

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