Table 3 Clinical features of family subsets identified by OSA. For chromosome 16p12, OSA-defined subsets were obtained from an analysis of 45 multiplex families (at least 2 sampled relatives with late AMD, grade 3 not considered affected). For the other two regions, OSA-defined subsets were obtained from an analysis of all 62 multiplex families (at least 2 sampled relatives with early or late AMD).
Region | OSA covariate | No. fams in subset | Avg. no. affecteds/ family | No. affected indiv. | Grade 3 | Grade 4 | Grade 5 | Average covariate value in affected individuals | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Â | Â | Â | Age | BMI | SBP | DBP | IOP | PKYRS |
6q14 | BMI | 8 | 2.3 | 18 | 6 (33.3) | 1 (5.6) | 11 (61.1) | 70.3 | 31.4 | 133.9 | 74.5 | 16.8 | 24.5 |
14q13 | IOP | 28 | 2.3 | 65 | 17 (26.2) | 12 (18.5) | 36 (55.4) | 75.8 | 25.9 | 135.2 | 75.1 | 13.9 | 24.9 |
16p12 | SBP | 25 | 2.4 | 61 | - | 18 (29.5) | 43 (70.5) | 75.0 | 25.6 | 145.0 | 78.2 | 16.2 | 21.3 |
| Â | IOP | 32 | 2.5 | 79 | - | 19 (24.1) | 60 (75.6) | 75.7 | 26.2 | 139.6 | 77.7 | 17.3 | 19.6 |
| Â | BMI | 9 | 2.7 | 24 | - | 4 (16.7) | 20 (83.3) | 74.5 | 29.3 | 137.2 | 74.4 | 17.2 | 25.5 |
| Â | Â | Â | 62 families: 2+ sampled relatives with early or late AMD | ||||||||||
| Â | Â | Â | 2.4 | 147 | 29 (19.7) | 31 (21.1) | 87 (59.2) | 74.8 | 26.2 | 136.8 | 76.6 | 16.0 | 21.1 |
| Â | Â | Â | 45 families: 2+ sampled relatives with late AMD | ||||||||||
| Â | Â | Â | 2.4 | 106 | - | 27 (25.5) | 79 (74.5) | 76.3 | 25.7 | 137.8 | 76.4 | 16.1 | 22.5 |