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Table 3 Results of meta-analysis of 39 studies (N = 10,738 cases and 17,068 controls) of the association of PON1 Q192R genotype with coronary heart disease (CHD)

From: The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

  OR (95% CI) for myocardial infarction OR (95% CI) for angina OR (95% CI) for any CHD
Dominant model
Fixed effect 1.10 (1.03, 1.18) 1.18 (1.09, 1.27) 1.14 (1.08, 1.20)
Random effect 1.12 (1.01, 1.23) 1.26 (1.08, 1.46) 1.19 (1.08, 1.30)
p heterogeneity 0.08 < 0.001 < 0.001
Recessive model
Fixed effect 1.14 (1.01, 1.28) 1.12 (1.00, 1.25) 1.13 (1.04, 1.22)
Random effect 1.14 (1.01, 1.28) 1.14 (0.99, 1.33) 1.13 (1.02, 1.24)
p heterogeneity 0.72 0.01 0.08
Per allele
Fixed effect 1.06 (1.01, 1.12) 1.13 (1.06, 1.20) 1.10 (1.06, 1.13)
Random effect 1.07 (1.01, 1.13) 1.15 (1.05, 1.24) 1.11 (1.06, 1.15)
p heterogeneity 0.12 < 0.001 < 0.001
  1. OR: odds ratio; CI: confidence interval; CHD: coronary heart disease
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BMC Genomic Data

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