Table 3 Results of meta-analysis of 39 studies (N = 10,738 cases and 17,068 controls) of the association of PON1 Q192R genotype with coronary heart disease (CHD)
| Â | OR (95% CI) for myocardial infarction | OR (95% CI) for angina | OR (95% CI) for any CHD |
|---|---|---|---|
Dominant model | |||
Fixed effect | 1.10 (1.03, 1.18) | 1.18 (1.09, 1.27) | 1.14 (1.08, 1.20) |
Random effect | 1.12 (1.01, 1.23) | 1.26 (1.08, 1.46) | 1.19 (1.08, 1.30) |
p heterogeneity | 0.08 | < 0.001 | < 0.001 |
Recessive model | |||
Fixed effect | 1.14 (1.01, 1.28) | 1.12 (1.00, 1.25) | 1.13 (1.04, 1.22) |
Random effect | 1.14 (1.01, 1.28) | 1.14 (0.99, 1.33) | 1.13 (1.02, 1.24) |
p heterogeneity | 0.72 | 0.01 | 0.08 |
Per allele | |||
Fixed effect | 1.06 (1.01, 1.12) | 1.13 (1.06, 1.20) | 1.10 (1.06, 1.13) |
Random effect | 1.07 (1.01, 1.13) | 1.15 (1.05, 1.24) | 1.11 (1.06, 1.15) |
p heterogeneity | 0.12 | < 0.001 | < 0.001 |