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Table 2 Number of main haplotypes observed within genes compared to the number of possible haplotypes and yin yang haplotype distribution

From: Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes

Gene

Chromosome location

No. of SNPs

Kb spanned

SNP density (kb/SNP)

Observed No. of haplotypesa

Expected No. of haplotypes

Yin Yang haplotypesb

ApoE

19q13.2

4

3

0.75

6

16

GATC, CGTC

COL1A1

17q21.3-q22

3

16

5.33

4

8

GGG, GTG

ER-α

6q25.1

7

291

41.57

20

128

TCGCGGG, CTGCGGG

LEPR

1p31.2

3

66

22

7

8

GCG, GGA

PTHR1

3p22-p21.1

4

9

2.25

7

16

GTAA, ACGC

TGF-β1

19q13.1

3

22

7.33

4

8

C+C, T+C-

UCP3

11q13.4

3

5

1.67

4

8

TCT, CTC

VDR

12q12-14

4

39

9.75

12

16

GTGT, GTAC

  1. a: Only haplotypes with frequencies more than 1% were included [14] b: For the PTHR1 and UCP3, Yin yang haplotypes were presented. For the other six genes, the two most common haplotypes were presented. The haplotypes were reconstructed based on the SNPs in the order from 5' to 3' on the chromosome within each gene.