Segregation analysis comparing liability and quantitative trait models for hypertension using the Genetic Analysis Workshop 13 simulated data

Table 3 Parameter estimates for quantitative trait segregation analyses of sex-adjusted height

Model	Allele frequency	Dominance	Displacement	Heritability	2lnL^a	Number of parameters
Sporadic	(-)	(-)	(-)	(0)	0	0
Polygenic	(-)	(-)	(-)	0.77	2607.39	1
Single genes
Codominant	0.39	0.45	3.58	(0)	2394.36	3
Mixed models
Codominant	0.35	0.34	2.53	0.64	2810.17	4
2-locus models
Locus 1	0.53	0.49	3.25
Locus 2	0.34	0.35	3.19	(0)	2792.91	6
2-locus mixed model
Locus 1	0.38	0.52	2.61
Locus 2	0.33	0.26	2.92	0.48	2842.52	7

^A Twice log likelihood difference from sporadic model. Parameters in parentheses fixed. For a single locus model with three alleles at fixed frequencies (0.4, 0.3, and 0.3), 12 parameters were estimated (genotypic means and standard deviations) which maximize at 2lnL = 2750.89; with the additional heritability parameter (13 parameters estimated) 2lnL = 2849.08 and h² = 0.552.

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