Segregation analysis comparing liability and quantitative trait models for hypertension using the Genetic Analysis Workshop 13 simulated data

Table 2 Parameter estimates from qualitative trait segregation analyses of hypertension (including incidence data)

Model	Allele frequency	Dominance	Displacement	Heritability	2lnL^A	Number of parameters
Sporadic	(-)	(-)	(-)	(0)	0	0
Polygenic	(-)	(-)	(-)	1.00	3623.09	1
Single genes
Dominant	0.05	(1)	2.98	(0)	3208.07	2
Recessive	0.33	(0)	3.47	(0)	3130.10	2
Codominant	0.07	0.66	4.63	(0)	3421.01	3
Mixed models
Dominant	0.21	(1)	77.4	1.00	3848.22	3
Recessive	0.73	(0)	5.51	1.00	3779.37	3
Codominant	0.20	0.99	76.9	1.00	3988.55	4
2-locus model
Locus 1	0.15	0.76	2.94
Locus 2	0.07	0.75	6.10	(0)	3620.38	6
2-locus mixed model
Locus 1	0.07	0.02	3.08
Locus 2	0.18	0.99	102.41	1.00	4002.82	7

^A Twice log likelihood difference from sporadic model. Parameters in parentheses fixed. Maximizations at parameter boundaries (heritability 1.0) were further evaluated confirming that the true maximum was attained.

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