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Table 5 Unblinded major pleiotropic genes influencing TG and HDL-linkage results.

From: Exploring pleiotropy using principal components

  PC 1 PC 2 PC 3
  1/2 (Log Chol + LDL) PC 2 1/2 BMI + (Log TG - HDL) PC 3 Log SBP + 2/3 BMI
Gene Max LODA H2rB H2q1B Max LODA H2rB H2q1B Max LODA H2rB H2q1B
G(b12) C 0.00 0.62 0.00 0.00 0.80 0.00 0.42 0.71 0.05
G(b13) D 0.00 0.62 0.00 0.00 0.80 0.00 0.24 0.72 0.03
  1. AMaxLOD, the maximum LOD score within approximately 20 cM of the gene.
  2. BH2r represents the polygenic contribution and H2q1 the contribution of major gene (H2r + H2q1 = overall heritability).
  3. CG(b12) is located on chromosome 9 at 11 cM (MaxLOD range: 0 cM-35 cM).
  4. DG(b13) is located on chromosome 9 at 83 cM (MaxLOD range: 65 cM-105 cM).
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