Skip to main content

Table 5 Unblinded major pleiotropic genes influencing TG and HDL-linkage results.

From: Exploring pleiotropy using principal components

 

PC 1

PC 2

PC 3

 

1/2 (Log Chol + LDL)

PC 2 1/2 BMI + (Log TG - HDL)

PC 3 Log SBP + 2/3 BMI

Gene

Max LODA

H2rB

H2q1B

Max LODA

H2rB

H2q1B

Max LODA

H2rB

H2q1B

G(b12) C

0.00

0.62

0.00

0.00

0.80

0.00

0.42

0.71

0.05

G(b13) D

0.00

0.62

0.00

0.00

0.80

0.00

0.24

0.72

0.03

  1. AMaxLOD, the maximum LOD score within approximately 20 cM of the gene.
  2. BH2r represents the polygenic contribution and H2q1 the contribution of major gene (H2r + H2q1 = overall heritability).
  3. CG(b12) is located on chromosome 9 at 11 cM (MaxLOD range: 0 cM-35 cM).
  4. DG(b13) is located on chromosome 9 at 83 cM (MaxLOD range: 65 cM-105 cM).
Back to article page

BMC Genomic Data

ISSN: 2730-6844

Contact us