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Table 2 Linkage detection on 5 chromosomes with SBP genes using ASP linkage analysis and OSA.A

From: Adjusting for covariates on a slippery slope: linkage analysis of change over time

Analysis

Chr 5

Chr 7

Chr 13

Chr 15

Chr 21

SIBLINK ASP on HBP OSA

0.52 (63)

0.16 (199)

0.0 (--)

0.92 (109)

2.03 (56)

   NormB SBP slope (affecteds only)

1.87 (58) p = 0.45

p = 0.003

0.88 (28) p = 0.04

2.81 (5) p = 0.04

3.28 (63) p = 0.16

   Norm SBP slope (all individuals)

1.99 (39) p = 0.27

3.13 (124) p = 0.01

2.14(117) p = 0.04

3.61 (99) p = 0.009

2.10 (56) p = 0.80

   SBP slope (affecteds only)

2.24(127) p = 0.17

p = 0.12

3.88 (91) p = 0.005

2.53 (105) p = 0.094

2.57 (53) p = 0.58

   SBP slope (all individuals)

2.12(112) p = 0.27

2.91 (12) p = 0.03

3.29 (91) p = 0.01

2.36 (106) p = 0.13

2.91 (57) p = 0.38

   Norm adjusted SBP slope (affecteds only)

1.25(63) p = 0.66

2.07 (140) p = 0.13

1.01 (43) p = 0.44

1.87 (109) p = 0.23

2.37 (53) p = 0.62

   Norm adjusted SBP slope (all individuals)

1.84(214) p = 0.39

2.50 (107) p = 0.05

3.23(118) p = 0.02

2.11 (99) p = 0.14

2.75 (53) p = 0.44

   Adjusted SBP slope (affecteds only)

2.41(112) p = 0.17

1.16 (123) p = 0.58

3.69 (91) p = 0.009

1.74 (108) p = 0.38

2.88 (55) p = 0.27

   Adjusted SBP slope (all individuals)

2.12(112) p = 0.29

2.08 (99) p = 0.05

3.01(122) p = 0.05

1.97 (107) p = 0.19

2.91 (53) p = 0.32

   Norm "true" SBP slope (affecteds only)

1.34 (61) p = 0.74

2.08 (123) p = 0.15

0.94 (91) p = 0.41

1.96 (108) p = 0.23

2.92 (62) p = 0.45

   Norm "true" SBP slope (all individuals)

2.14(214) p = 0.25

2.44 (124) p = 0.06

2.54(117) p = 0.05

2.20 (106) p = 0.14

2.72(52) p = 0.44

   "True" SBP slope (affecteds only)

2.12(112) p = 0.19

1.95 (37) p = 0.16

4.26 (91) p = 0.002

1.95 (108) p = 0.23

2.92 (55) p = 0.34

   "True" SBP slope (all individuals)

2.16(209) p = 0.24

2.37 (99) p = 0.07

3.56 (91) p = 0.009

1.89 (108) p = 0.24

3.15 (58) p = 0.17

True location of SBP genes (cM)

B34 (176)

B36 (47)

B35 (85)

S11 (4.5)

S12 (29) S10 (54)

  1. AValues in the table are the maximum LOD score and the location in cM. BNorm, normalized.
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BMC Genomic Data

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