Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach

BMC Genomic Data

Table 1 Linkage analyses results for mean, slope and baseline measure at Exam 1

			Multipoint LOD scores at CHCL genes (QTLh²)
			Slope Genes			Baseline Genes
	No. Subjects	Total h²	S7	S8	S9	B30	B31	B32	B33	Number of False Positives (LOD scores)
Baseline	2869	0.55	3.1 (.20)	0.6	0.0	5.3 (.27)	3.1 (.21)	8.1 (.30)	0.0	1 (3.1)
Mean	2812	0.60	10.6 (.33)	1.3	0.0	2	2.8	6.8 (.26)	0.0	1 (3.3)
Slope	2698	0.42	10.3 (.33)	0.25	0.0	0.0	0.0	0.0	0.0	2 (4.3, 3.6)

The table contains number of subjects, total heritability and multipoint LOD scores at slope or baseline CHOL genes; and LOD score peaks ≥ 3 at locations where no CHOL genes existed (false positives) for baseline measure at Exam 1, mean definition 2 and slope. LOD scores in bold indicate genome-wide significant results using LOD = 3 as a threshold. QTL heritabilities for the detected true genes were also presented next to the LOD scores.

ISSN: 2730-6844