Figure 2From: Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usageAlignment of myocilin orthologs. Alignment of rabbit, human, monkey, mouse, rat, and bovine myocilin amino acid sequences. Identical amino acids are shaded and missing amino acids are indicated with a dash. The 14 amino acid deletion in human MYOC plasmid pcDNA3.hMYOC.ΔN14 is underlined. The putative myocilin signal peptide is boxed. Location of the predicted N-linked glycosylation site (human myocilin Asn57) is indicated with a 'n'. Locations of predicted O-linked glycosylation sites are marked with an 'o'. The leucine zipper motif is marked by dots. Disease-causing mutations identified based on experimental data and statistical arguments with glaucoma family pedigrees and documented in the Human Gene Mutation Database http://uwcmml1s.uwcm.ac.uk/uwcm/mg/search/5584221.html are indicated with a 'x'. GenBank accession numbers are as follows: rabbit, AY191317; human, NM_000261; monkey, AY190128, AY190129, AY190130; mouse, AF039869; rat, AF093567; bovine, AB027758.Back to article page