Figure 3

Male preponderance in early diagnosis is associated with the ARE2 variant. A. Ratio of females to males in the total DARTS type 2 population (n= 8155) and in the genotyped subgroup (Go-DARTS, n = 1950) by quintile of age diagnosed B. Ratio of females to males in Go-DARTS by ARE genotype by quintile of age diagnosed. Quintiles were used to maintain equal numbers of individuals in each category and are defined as follows: DARTS: 1=under 48 yrs; 2, 48–56 yrs; 3 = 57–63 yrs; 4 = 64–70 yrs; 5= over 70 yrs. Go-DARTS: 1= under 45 yrs; 2 = 45–54 yrs; 3 = 55–60 yrs; 4 = 60–67 yrs; 5, = over 67 yrs.)