Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposure

Table 1 Differences in clinical, pathological, and CGH findings by status of carcinogen exposure.

	Overall	Tobacco/Alcohol (-)	Tobacco/Alcohol (+)	p-value
Median age	61 years	53 years	64.5 years	.002^A
Male gender (n, %)	47 (66%)	10 (67%)	37 (66%)	NS^B
TNM Stage (n, %)
I-II	17 (24%)	3 (20%)	14 (25%)	NS^B
III-IV	54 (76%)	12(80%)	42 (75%)
Nodal metastasis at presentation	37 (52%)	7 (47%)	30 (54%)	NS^A
Treatment (n, %)
Surgery based	36 (51%)	8 (53%)	28 (50%)	NS^A
Radiation based	35 (49%)	7 (47%)	28 (50%)
Second primary cancers	8 (11%)	2 (13%)	6 (11%)	NS^B
Median follow-up (months)	38	47 months	38 months	NS^A
Recurrence (n, %)	24 (34%)	7 (47%)	17 (30%)	NS^B
Death- from cancer	18 (25%)	4 (27%)	14 (25%)	NS^B
Death- any cause	26 (36%)	6 (40%)	20 (36%)	NS^B
3 year disease free survival	55%	47%	58%	NS^D
3-year cause specific survival	72%	81%	69%	NS^D
3-year overall survival	65%	67%	64%	NS^D
Median # of gains*	6	4	6	NS^B
Median # of losses*	2	3	2	NS^B
Median # of abnormalities*	9	8	9	NS^B

*Determined by calculation of individual, continuous chromosomal gains, losses and amplifications identified by CGH analysis. ^A Mann-Whitney U test ^B Fisher's exact test ^C Chi Square ^D Log rank test

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